Molecular duo dictate human weight and energy levels

ScienceDaily (Feb. 28, 2012) ? Yale University researchers have discovered a key cellular mechanism that may help the brain control how much we eat, what we weigh, and how much energy we have.

The findings, published in the Feb. 28 issue of the Journal of Neuroscience, describe the regulation of a family of cells that project throughout the nervous system and originate in an area of the brain call the hypothalamus, which has been long known to control energy balances.

Scientists and pharmaceutical companies are closely investigating the role of melanin-concentrating hormone (MCH) neurons in controlling food intake and energy. Previous studies have shown that MCH makes lab animals eat more, sleep more, and have less energy. In contrast, other hypothalamic neurons use the thyrotropin-releasing hormone (TRH) as a neurotransmitter, and these neurons reduce food intake and body weight, and increase physical activity.

The Yale study of brains of mice shows that the two systems appear to act in direct opposition, to help the organism keep these crucial functions in balance.

Although TRH is normally an excitatory neurotransmitter, the Yale study shows that in mice TRH inhibits MCH cells by increasing inhibitory synaptic input. In contrast, TRH had little effect on other types of neurons also involved in energy regulation.

"That these two types of neurons interact at the synaptic level gives us clues as to how the brain controls the amount of food we eat, and how much we sleep," said Anthony van den Pol, senior author and professor of neurosurgery at Yale School of Medicine.

The co-author of the paper is Xiaobing Zhang of Yale.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Yale University. The original article was written by Bill Hathaway.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120228190920.htm

stanford oregon velasquez vs dos santos velasquez vs dos santos manny pacquiao vs. juan manuel marquez manny pacquiao vs. juan manuel marquez cain velasquez vs dos santos cain velasquez vs dos santos