Source: http://www.thehollywoodgossip.com/2013/05/the-worlds-end-posters-cheers/
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Wednesday, May 22, 2013
Just like their annual Zeitgeist roundup of its most-searched-for terms, Google Trends now offers mo
Just like their annual Zeitgeist
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Editorial: Engadget on the Xbox One
At long last, Microsoft unveiled its next-generation gaming console today, the Xbox One. As expected, its hardware stacks up well with the Wii U and PlayStation 4, and the launch event showcased some slick new software, too. With tight fantasy sports integration, Windows 8 and Skype support and cooperation with live TV, the One looks to have taken the next step in transforming the Xbox from a gaming rig into a true home entertainment console. It's a rare thing to get to opine on a new game console, so head on past the break and allow us to indulge this opportunity.
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/8hYIYuTPr-Y/
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Riots in Stockholm suburb over police shooting
STOCKHOLM (AP) ? Gangs of youth angered by the police shooting death of an elderly man in a mainly immigrant neighborhood hurled rocks at police and set cars and buildings on fire in a Stockholm suburb early Monday, forcing the evacuation of an apartment block.
Around 50 youths were involved in the riots in the suburb of Husby, police spokesman Lars Bystrom said.
The youths set light to a parking garage, compelling police to evacuate residents from an adjacent apartment block, Bystrom said. Residents were allowed to return home after a couple of hours.
Around 80 percent of the roughly 11,000 people living in Husby ? a drab, low-income neighborhood of apartment blocks west of Stockholm ? are first or second generation immigrants.
Bystrom said police responded to calls of burning cars and were met by masked youths hurling rocks at them.
One policeman was attacked by youths kicking him and two others were injured by rocks, local police officer Jorgen Karlsson said. He added around 10 cars were set ablaze, and windows were smashed at two schools and several local businesses.
Karlsson said the dead man was "European," but couldn't specify his nationality.
Residents said they had gathered to protest against the shooting death and that police responded by sending in SWAT teams that cordoned off the area.
"I understand that people react like this," said Rami Al-Khamisi from the organization Megafonen, which represents citizens in Stockholm's suburbs.
The organization said police had used excessive violence against the youths and also attacked passers-by with batons and dogs.
Police have launched an internal probe to investigate the shooting death on May 13 of a 69-year-old man in Husby. They say they shot the man in self-defense because he had attacked police with a knife when they broke down the door to an apartment, where he had locked himself up with a woman.
However, Megafonen has criticized police for initially releasing a faulty report saying the man was taken to a hospital. The group said residents had seen his dead body being transported from the scene hours after the shooting in a hearse, which police later admitted was correct.
Source: http://news.yahoo.com/riots-stockholm-suburb-over-police-shooting-151632157.html
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Tuesday, May 21, 2013
This Week in Small Business: Gordon Ramsay Calling! - NYTimes.com
Dashboard
A weekly roundup of small-business developments.
What?s affecting me, my clients and other small-business owners this week.
Must-Reads
Tim Duy explains what Japan?s growth means for the rest of the world. And here are the social media lessons from a Gordon Ramsay nightmare gone viral.
The Economy: Cash Is Not Safe
Retail sales rise and household debt declines, driven largely by lower housing and credit card balances. Corporate earnings are at a historic high. The latest small-business confidence index ticks up. Builder confidence improves, too. But April?s producer prices and industrial production both fell, and the latest business inventories and sales numbers continue to show little improvement. A forecast predicts a plunge in gasoline prices. Business conditions in the New York region (pdf) deteriorate, and the New York Federal Reserve Bank says tight credit is restraining small-business growth. David Rosenberg explains why cash is your least safe bet, and Rex Nutting is convinced that everything is overvalued: ?No one?s sure when the reckoning will take place, but it?s likely to be ugly when it does.? Joseph Biden agrees with a 7-year-old?s suggestion to make the world a better place.
Washington: Sequestration Watch
The Congressional Budget Office says the deficit problem is solved for the next 10 years. Paul Krugman says the case for austerity has crumbled, but Keith Hennessey says it?s too soon to celebrate. Jared Bernstein submits the fourth installment of his ?sequester watch.? The Federal Reserve, whose policy has pushed some start-ups to be valued at a billion dollars, may ease up on monetary easing this summer. Here are a few buzzwords to watch as the Fed plots its exit strategy. Joe Weisenthal reveals the real reason people bash Ben S. Bernanke and John Maynard Keynes at conferences. A bunch of economists offer advice to graduates.
Your People: Hourly Workers
Alex Befekadu lists seven employee types that you should fire. Joanne Sammer takes a look at what constitutes a healthy work/life balance and how companies can achieve that goal. A study finds that freedom is the top reason for quitting and that millennials want to be entrepreneurs (but that doesn?t always mean starting businesses). Here are four steps to hiring hourly workers this summer. Crispin Jones explains the benefits of having a diverse workplace. Here are five ways to deliver bad news to employees (and the best ways to open a beer).
Finance: A Trip to Mars
Andr? Mouton believes that if venture capitalists aren?t interested in crowdfunding, maybe you should be (apparently, Donald Trump is interested). Jeff Hindenach explains why credit cards remain a viable option for small businesses. Kabbage expands its small-business financing (using QuickBooks data), and NASA is offering $9.8 million to small and midsize businesses for a trip to Mars. Joe Taylor gives advice for building a profitable banking relationship, but here are some alternatives if you cannot. And here are two helpful online valuation tools to find out how much your business is worth. Bayer HealthCare goes on a start-up hunt. Retiring baby boomers are driving the sales of small businesses.
Start-Up: Controlling Fear
Ken Oboh says start-ups should ditch their ?go big or go home? mentality. Peter Thiel?s first investment in Europe has gone to a London-based start-up in financial technology. A life coach explains how to control the fear of starting a small business. Two start-up founders were not afraid to sleep in a van for months on end. Here?s how start-ups can get cheap office space and three ways to jump-start your dreams. Morgan Hartley and Chris Walker explain why your city needs a start-up scene. A venture capital firm is eager to invest in start-ups in Charlotte, N.C. A start-up ?dream team? is looking for 45 young aspiring entrepreneurs from around the world to join a nine-week summer program in Silicon Valley. This is how one entrepreneur started three businesses by age 32.
Management: Go to Bed
Todd Wasserman explains key performance indicators. Julia Kirby says that if you want to change the world, you should get to bed by 10 p.m. Here are eight easy ways for your business to go green, and Jim Smith explains what your business can learn from the?$1 cups at Starbucks. Communicating with energy is one of the five most important business skills. According to an American Express study, 70 percent of entrepreneurs say they purchase and source goods and services from other small businesses. A survey reveals the DNA of America?s small-business owners.
Marketing: The Ultimate Pitch
Here is how Lowe?s is making its customers smarter with six-second videos on Vine. Pamela Wilson has suggestions for getting customer testimonials that will convince even the most skeptical prospects. Mark Emond writes that there are four foundational elements of marketing analytics success. Suren Ter-Saakov explains what is important about competitive analysis. Diane Carlson warns not to make these business card mistakes. Jill Konrath says this is the ultimate sales pitch. A contract manufacturer shares eight marketing tips.
Around the Country: A $50,000 Challenge
An Alaskan town will vanish by 2017. In tornado-hit Joplin, Mo., employees of local businesses chip in again to rebuild. A new Colorado law provides recourse for discrimination against workers at companies that employ fewer than 15 people. Constant Contact joins with Staples and Score to host free webinars. CNBC?s new small-business show introduces a $50,000 challenge. In Chicago, mothers are showing their children the real estate ropes. In Pennsylvania, four businesses receive energy-efficiency and pollution-prevention grants, registration opens for a small-business expo on government contracting and a small-business conference plans a summer debut in Philadelphia.
Around the World: Manufacturers Coming to U.S.
The euro zone recession continues into its sixth quarter, and the social mood darkens. The United States oil boom leaves OPEC sidelined from demand growth. Japan?s economy expands faster than expected. A youth hockey brawl breaks out in Russia. China?s industrial production grew 9.3 percent in April. Jeffrey Telep and Joshua Snead report that global manufacturers are moving production to the United States. The proportion of British-based small businesses targeting the growing international market for low-carbon products has doubled in the past two years.
Social Media: Exclamation Points
Amanda McCormick wants to know how you are using social media to market your business. Dan Zarrella finds that exclamation points get more retweets but fewer clicks. LinkedIn bans users from promoting prostitution and escort services, but this is not why the social media service annoys Benedict Evans. Christopher Null wonders if Google Plus matters for small businesses.
Red Tape: Deficiencies
The Government Accountability Office finds 60 deficiencies in the Internal Revenue Service?s internal controls, and Jon Stewart weighs in. The Obama administration announces three advanced manufacturing innovation institutes. A survey reveals a lingering uphill battle for the new health care law, but Emily Maltby and Angus Loten wonder whether the law may create new entrepreneurs. Sarah Kliff explains what will happen if you don?t pay the tax penalty, and a small-business owner explains the hard facts of the health care law to employees.
Online: Call to Action!
Seth Godin explains why they call it a browser: ?Call it attention inflation. More time spent looking, less time spent clicking.? A company that provides legal services to small businesses is now accepting Bitcoin as payment (and Amazon introduces its own virtual currency). OpenSky becomes another ?interesting competitor? in the online marketplace. Here are some keyword strategies to draw people to your site, and here is how to use calls to action in your next e-mail campaign. Roger Kohl tells you everything you need to know about ?the scariest search engine? on the Internet. Here are Time magazine?s best Web sites of 2013, and here are 16 steps to hosting a successful webinar. Did you know that 70 percent of consumers trust online reviews?
Retail: Bike Lanes Are Good
Square unveils hardware for its point-of-sale iPad registers, Groupon officially introduces its own point-of-sale system, and PayPal unveils a program to compel small merchants to throw away their cash registers. Also, keep your eyes on these shopping-cart-mounted tablets that will detect nearby items and offer recipes in real time. Fred Lizza says cloud retail can transform your business, and these are the benefits of a cloud-based inventory management system. A survey finds restaurant sales and traffic improved in April. Restaurant marketers are waking up to a $50 billion breakfast opportunity, and millennials are propelling the growth of the sandwich industry. Bike lanes happen to be good for local businesses.
Mobile: Dead in the Water
Nearly 75 percent of all smartphones sold in the first quarter were Android-based, and this chart shows that the iPhone?s market share is ?dead in the water.? It is now estimated that the mobile marketing industry may employ 1.4 million people by 2015. Tobin Dalrymple suggests five ways to publish content on mobile. Here is a guide to mobile productivity apps, and Brian S. Hall shares six mobile apps created by nontech companies. Jon Gold explains why everyone is still confused by mobile management. BlackBerry will introduce BBM for iOS and Android this summer. A coming webinar looks at small-business adoption of mobile.
Technology: Texting to Landlines
Google is offering free unified storage across its services along with a way to send money by Gmail. Here is everything Google announced at its developer?s conference (which is also where the company?s chief executive said he wanted to start his own country). A company introduces texting to landlines. Michael del Castillo shares the lessons learned from five huge tech flops. Megan Totka suggests five customer relationship management tools for small businesses.?Windows Blue may leave customers seeing red.
Tweet of the Week
@dansinker ? How long does a keynote have to last before it?s considered a hostage situation?
The Week?s Best Quote
Charlie Hamilton shares a few lessons from the lemonade stand: ?Successful adults often worked when they were young. They mowed lawns, baby-sat, or had a lemonade stand. Learning how to work hard, provide good customer service, overcome challenges, ask for the sale, and understand the value of a dollar are invaluable life lessons that kids simply can?t get from a textbook.?
This Week?s Question: Would you buy a point-of-sale system from Groupon?
Gene Marks owns the Marks Group, a Bala Cynwyd, Pa., consulting firm that helps clients with customer relationship management. You can follow him on Twitter.
Source: http://boss.blogs.nytimes.com/2013/05/20/this-week-in-small-business-gordon-ramsay-calling/
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Monday, May 20, 2013
Study identifies new approach to improving treatment for MS and other conditions
Monday, May 20, 2013
Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.
The findings of the research study, published online today in the journal EMBO Molecular Medicine could have therapeutic applications for MS as well as cerebral palsy and leukodystrophies, all disorders associated with loss of white matter, which is the brain tissue that carries information between nerve cells in the brain and the spinal cord.
The target, a protein referred to as mitochondrial translocator protein (TSPO), had been previously identified but not linked to MS, an autoimmune disease that strips the protective fatty coating off nerve fibers of the brain and spinal cord. The mitrochronical TSPO is located on the outer surface of mitochondria, cellular structures that supply energy to the cells. Damage to the fatty coating, or myelin, slows the transmission of the nerve signals that enable body movement as well as sensory and cognitive functioning.
The scientists identified mitochondrial TSPO as a potential therapeutic target when mice that had symptoms of MS improved after being treated with the anti-anxiety drug etifoxine, which interacts with mitochondrial TSPO. When etifoxine, a drug clinically available in Europe, was administered to the MS mice before they had clinical signs of disease, the severity of the disease was reduced when compared to the untreated lab animals. When treated at the peak of disease severity, the animals' MS symptoms improved.
"Etifoxine has a novel protective effect against the loss of the sheath that insulates the nerve fibers that transmit the signals from brain cells," said Wenbin Deng, principal investigator of the study and associate professor of biochemistry and molecular medicine at UC Davis.
"Our discovery of etifoxine's effects on an MS animal model suggests that mitochondrial TSPO represents a potential therapeutic target for MS drug development," said Deng.
"Drugs designed to more precisely bind to mitochondrial TSPO may help repair the myelin sheath of MS patients and thereby even help restore the transmission of signals in the central nervous system that enable normal motor, sensory and cognitive functions," he said.
Deng added that better treatments for MS and other demyelinating diseases are needed, especially since current FDA-approved therapies do not repair the damage of immune attacks on the myelin sheath.
The UC Davis research team hopes to further investigate the therapeutic applications of mitochondrial TSPO in drug development for MS and other autoimmune diseases. To identify more efficacious and safer drug candidates, they plan to pursue research grants that will enable them to test a variety of pharmacological compounds that bind to mitochondrial TSPO and other molecular targets in experimental models of MS and other myelin diseases.
The journal paper is entitled, "A TSPO ligand is protective in a mouse model of multiple sclerosis."
###
University of California - Davis Health System: http://www.ucdmc.ucdavis.edu
Thanks to University of California - Davis Health System for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Xbox to flash steel in new console war
xbox 
3 hours ago
Microsoft
Microsoft will introduce its contestant for the next generation of the video game console wars next week.
It's like a seven-year storm: High-pressure fronts from Sony, Nintendo and Microsoft come together creating high winds and stormy seas, with the world's gamers sitting ? and grinning ? right in the eye of it all. Yes, the next console war is on.
Nintendo started it. Last November, the House of Mario released the quasi-next-generation Wii U console to middling results. Sony made the next move, officially announced the next PlayStation system in February, promising it for the 2013 holidays. But nobody outside of the company even knows what the device looks like, much less what it will cost.
The Internet has been devouring itself with hype and rumors about the next Xbox, but Microsoft itself has barely made a sound. Finally, on May 21, the company will reveal its game plan ? and hopefully the system itself.
While it's not clear what it will be called, the three leading contenders are "Xbox Infinity," the painfully logical "Xbox 720" and the minimalist "Xbox." The rumor mill's consensus has settled around a few key features ? compatibility with Blu-ray, social-media integration, revamped motion control that builds on the Xbox 360's wildly successful Kinect add-on. The system is likely to have integrated Skype video chat as well, since Microsoft owns it. Controversially, the device is also expected to feature some kind of "always-online" requirement, meaning that users will need a stable Internet connection to access both gaming and non-gaming content.
Though there has been discussion about Microsoft also building an "Xbox TV" set-top box, it seems that the company is focusing, for now, on turning the new game console into an entertainment hub, one that can connect to cable boxes, and also feature original content. Microsoft has been tight-lipped about what's coming from its first-party entertainment studio, but the very existence of such an operation shows that it wants to better compete with Amazon and Netflix, which both offer non-broadcast shows.
Stacking up
Will these new features be enough to keep Xbox competitive with its peers? Sony hasn't said much about entertainment features in its PlayStation 4. And while the company is championing social features ? even adding a "Share" button into the PS4 controller ? it didn't go into details of motion control. Instead, Sony is highlighting its starting line-up of AAA and indie games.
Microsoft will be talking up games as well. Activision has teased the fact that it will reveal the next title in its juggernaut "Call of Duty" franchise alongside the new Xbox. Meanwhile, rumor has it that Microsoft may have an exclusive deal with EA's upcoming "Call of Duty" rival "Titan."
Sony
Sony unveiled the PlayStation 4 this past February. While the company spent a lot of time showing off its redesigned controller, it still hasn't let anybody know what the actual console box is going to look like.
Both Sony and Nintendo have larger fleets of in-house studios to turn out original and exclusive games, which could leave Microsoft scrambling to find the next "Halo." But whatever the case, experts say Microsoft has a large enough install base to court any serious console developer.
"The biggest challenge this time is that Microsoft isn't getting a head start on Sony. And the second biggest one is that they're highly likely not getting a big price advantage over Sony," Michael Pachter, a prominent game industry analyst at Wedbush Securities, told NBC News. "Their advantage last time was that Sony was a year late, and the PS3 was $200 more expensive."
In 2005, Microsoft released the Xbox 360 a year before the Wii or PlayStation 3 hit shelves. Microsoft also priced its console much lower than the PS3. That advantage kept Xbox 360 sales a nose ahead of PlayStation 3's until just last winter, when they caught up overall. Now, it sounds like both consoles are coming out at the same time ? possibly even on the same week ? and are likely to be priced the same.
Pachter said that the only thing that might drive the new Xbox's price higher than the PS4's would be a mandatory Kinect add-on in every box, which he thinks would bump up the cost by $50. Otherwise, he said the two devices have "similar architecture" that would make them "comparably priced."
"We don't know about the Xbox yet, but if they both have this AMD chipset ? essentially the same power and the same graphics capability ? then they're both spending about the same to make their boxes. What else in the box really has cost?" Pachter also thinks the systems will have "big-ass hard drives," in the 1- to 2-terabyte range.
Oh, Nintendo
Pachter said that since Microsoft and Sony make remarkably "similar products competing for similar users," he doubted that either one would best each other in any substantive way. Rather, both stand to gain from the comparative weakness of Nintendo's faltering Wii U.
Nintendo's oddball inventions haven't always been an Achilles heel. Although the Xbox 360 and PlayStation 3 sold 76 million and 77 million consoles total worldwide by December 2012, according to an IDC report, Nintendo Wii blew both its competitors out of the water with 99.84 million units sold as of March 2013. Alas, Nintendo's streak is not likely to continue.
Nintendo
Nintendo was the first of the "big three" console developers to release a new console with the Wii U. Being the first to the punch hasn't done Nintendo any favors, though.
Game exclusivity, Nintendo's strong suit, can only take a console so far. Nintendo had the strongest brands known to the game industry behind the Wii U, and industry commentators have still written it off as a failure. Just last week, a developer at DICE all but dismissed the possibility of bringing any of its new games (including the wildly popular "Battlefield" franchise and any new "Star Wars" games that will come out of EA's recent partnership with Disney) to the Wii U.
Mario and Luigi can certainly help a new console get off the ground as they have many, many times for Nintendo, but they can't carry it for five to seven years. And given the sheer silliness of the Wii U's controllers, Microsoft could easily dominant motion-controlled gaming hardware with the Kinect alone.
"It's pretty obvious that Nintendo is going to sell fewer consoles this cycle," Pachter said.
Microsoft's main competition, then, will come from Sony's PlayStation 4, and once again gamers might be split pretty evenly. "If the next cycle is 300 million consoles, and Sony and Microsoft go from selling 85 million each to 110 million each, they're gonna be pretty happy about it," Pachter said.
The main question for gamers trying to choose between the two devices will mostly likely come down to which console has more of the games they want ? and more of their friends playing those games. Some people might be turned off by excessively draconian digital rights management, or wooed by better home entertainment options. But if pricing is even, the games are the thing.
Yannick LeJacq is a contributing writer for NBC News who has also covered games for Kill Screen, The Wall Street Journal and The Atlantic. You can follow him on Twitter at @YannickLeJacq and reach him by email at: ylejacq@gmail.com.
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Sunday, May 19, 2013
It's (Mostly) Official: Yahoo Buying Tumblr Youth Serum for $1.1B
Cash! The WSJ says "the Yahoo board has approved a deal" to make this happen, and it's hard to imagine Tumblr turning this down. One of the most unpopular
A billion dollars for a company with a massive, young, ad-averse, GIF-swapping user base and an open disdain for revenue?Yahoo's shareholders are probably a little puzzled, if they aren't prima facie dazzled by how often Tumblr is characterized as "cool" and "young"?that demographic elixer Yahoo will now try to vampire-suck out of Tumblr. Cool, cool, cool, young, young, so young.
Tumblr's investors won't be so dazzled, as they were hoping for a hell of a lot more than a billion dollars. Then again, these same investors poured millions into a company that, as mentioned, never made making money a priority?Tumblr should consider itself lucky to have this deus ex Marissa Mayer, the ultimate bail-out.
So, it's not ideal for either party, but that's Yahoo in 2013. It's a little sad and a little confusing, but the two deserve each other?and as AllThingsD's Kara Swisher reports, "There were no other competing bids." This is the internet acquisition equivalent of two tired, slightly desperate lovers exchanging leers from opposite sides of the bar, shrugging, and going home together. This is a Sure, why not, deal.
Still, no clues for the following questions:
A) What is Yahoo going to do with Tumblr in a way that justifies that giant price tag?
B) Will Tumblr have to start making money now?
C) What will Yahoo do with all of the porn and cutting
D) Is this the end of the road for unpopular boy king David Karp, who for the first time in his career will have to be accountable
We'll be at Yahoo's Manhattan announcement on Monday, but don't expect any big answers to the above?we don't suspect Yahoo even has them. The last we heard, Tumblr's employees will be called to hastily scheduled meetings Monday morning?rooms filled with dread and relief.
Source: http://valleywag.gawker.com/its-mostly-official-yahoo-buying-tumblr-for-1-1-bill-508716117
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AGA Research Foundation Research Scholar Awards advance the work of promising gastroenterologists
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 19-May-2013[ | E-mail |
Share ] Contact: Rachel Steigerwald
newsroom@gastro.org
301-272-1603
American Gastroenterological Association
Bethesda, MD (May 19, 2013) The American Gastroenterological Association (AGA) Research Foundation is pleased to announce its 2013 research scholars. This year's honorees are outstanding young gastroenterologists working toward independent careers in gastroenterology, hepatology or related areas, and with this award, their research time will be protected.
"These young researchers are the future of our field. AGA is committed to supporting young scholars who are paving the way for promising research developments and new therapies," said Nicholas F. LaRusso, MD, AGAF, chair of the AGA Research Foundation. "This year's honorees have embarked on their extraordinary research careers and demonstrate exceptional promise, and we look forward to seeing what they will accomplish with the help of this funding."
The 2013 AGA research scholars are:
- Edaire Cheng, MD, University of Texas Southwestern Medical Center, Dallas; Eosinophilic Esophagitis Fibrogenesis.
- Barham Abu Dayyeh, MD, MPH, Mayo Clinic, Rochester; Gastric and Hypothalamic Functions in Human Satiation.
- Hamed Khalili, MD, MPH, Massachusetts General Hospital; Oral Contraceptive Use in the Etiopathogenesis of Crohn's Disease.
AGA is also pleased to announce the AGA Institute President's Research Scholar honoree, a new award that will be presented every two years to an applicant of exceptional merit:
- Carol M. Aherne, PhD, University of Colorado, Denver; Epithelial Netrin-1 Controls CD4 Th1 T Cell Trafficking to the Inflamed Intestine.
The prestigious Research Scholar Awards provide $90,000 per year for two years (total $180,000) to the honorees to support their research. The goal of the Research Scholar Awards is to guarantee the perpetuation of strong science through the encouragement of young physician investigators and, ultimately, to improve patient care through digestive diseases research.
These extremely competitive awards ensure that bright, young scientists devote their careers to advancing the field of digestive health through research. Awards are based on the qualifications of the candidate, the quality of the candidate's research proposal and the commitment of the candidate's institution to support the required protected time for his or her research and adequate laboratory space.
The Research Scholar Awards program was launched in 1984 to provide crucial early support to investigators who show promise in academic gastroenterological research. The program's premise recognized that resources awarded early on could provide a stable platform from which future research funding would be derived. During and after their time as an AGA research scholar, recipients have made important contributions to the field of gastroenterology, and many former award recipients have gone on to hold distinguished appointments in major medical institutions in the U.S. and Canada.
The 2013 scholars were chosen by the AGA Research Awards Panel, a distinguished national advisory committee chaired by M. Bishr Omary, PhD, MD, professor and chair of the University of Michigan, Ann Arbor. Members of the committee include leading gastroenterologists from Beth Israel Deaconess Medical Center, Boston, MA; Mayo Medical Center, Rochester, MN; Mount Sinai Medical Center, New York, NY; Stanford University School of Medicine, CA; University of Pennsylvania, Philadelphia; among others.
###
About the AGA Research Foundation
The AGA Research Foundation, formerly known as the Foundation for Digestive Health and Nutrition, is the cornerstone of AGA's effort to expand digestive disease research funding. Since 1984, the AGA, through its foundations, has provided more than $40 million in research grants to more than 700 scientists. The AGA Research Foundation serves as a bridge to the future of research in gastroenterology and hepatology by providing critical funding to advance the careers of young researchers between the end of training and the establishment of credentials that earn National Institutes of Health grants. Learn more about the AGA Research Foundation or make a contribution at http://www.gastro.org/foundation.
About the AGA Institute
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. http://www.gastro.org.
Follow us on Twitter @AmerGastroAssn. Become an AGA fan on Facebook.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 19-May-2013[ | E-mail |
Share ] Contact: Rachel Steigerwald
newsroom@gastro.org
301-272-1603
American Gastroenterological Association
Bethesda, MD (May 19, 2013) The American Gastroenterological Association (AGA) Research Foundation is pleased to announce its 2013 research scholars. This year's honorees are outstanding young gastroenterologists working toward independent careers in gastroenterology, hepatology or related areas, and with this award, their research time will be protected.
"These young researchers are the future of our field. AGA is committed to supporting young scholars who are paving the way for promising research developments and new therapies," said Nicholas F. LaRusso, MD, AGAF, chair of the AGA Research Foundation. "This year's honorees have embarked on their extraordinary research careers and demonstrate exceptional promise, and we look forward to seeing what they will accomplish with the help of this funding."
The 2013 AGA research scholars are:
- Edaire Cheng, MD, University of Texas Southwestern Medical Center, Dallas; Eosinophilic Esophagitis Fibrogenesis.
- Barham Abu Dayyeh, MD, MPH, Mayo Clinic, Rochester; Gastric and Hypothalamic Functions in Human Satiation.
- Hamed Khalili, MD, MPH, Massachusetts General Hospital; Oral Contraceptive Use in the Etiopathogenesis of Crohn's Disease.
AGA is also pleased to announce the AGA Institute President's Research Scholar honoree, a new award that will be presented every two years to an applicant of exceptional merit:
- Carol M. Aherne, PhD, University of Colorado, Denver; Epithelial Netrin-1 Controls CD4 Th1 T Cell Trafficking to the Inflamed Intestine.
The prestigious Research Scholar Awards provide $90,000 per year for two years (total $180,000) to the honorees to support their research. The goal of the Research Scholar Awards is to guarantee the perpetuation of strong science through the encouragement of young physician investigators and, ultimately, to improve patient care through digestive diseases research.
These extremely competitive awards ensure that bright, young scientists devote their careers to advancing the field of digestive health through research. Awards are based on the qualifications of the candidate, the quality of the candidate's research proposal and the commitment of the candidate's institution to support the required protected time for his or her research and adequate laboratory space.
The Research Scholar Awards program was launched in 1984 to provide crucial early support to investigators who show promise in academic gastroenterological research. The program's premise recognized that resources awarded early on could provide a stable platform from which future research funding would be derived. During and after their time as an AGA research scholar, recipients have made important contributions to the field of gastroenterology, and many former award recipients have gone on to hold distinguished appointments in major medical institutions in the U.S. and Canada.
The 2013 scholars were chosen by the AGA Research Awards Panel, a distinguished national advisory committee chaired by M. Bishr Omary, PhD, MD, professor and chair of the University of Michigan, Ann Arbor. Members of the committee include leading gastroenterologists from Beth Israel Deaconess Medical Center, Boston, MA; Mayo Medical Center, Rochester, MN; Mount Sinai Medical Center, New York, NY; Stanford University School of Medicine, CA; University of Pennsylvania, Philadelphia; among others.
###
About the AGA Research Foundation
The AGA Research Foundation, formerly known as the Foundation for Digestive Health and Nutrition, is the cornerstone of AGA's effort to expand digestive disease research funding. Since 1984, the AGA, through its foundations, has provided more than $40 million in research grants to more than 700 scientists. The AGA Research Foundation serves as a bridge to the future of research in gastroenterology and hepatology by providing critical funding to advance the careers of young researchers between the end of training and the establishment of credentials that earn National Institutes of Health grants. Learn more about the AGA Research Foundation or make a contribution at http://www.gastro.org/foundation.
About the AGA Institute
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. http://www.gastro.org.
Follow us on Twitter @AmerGastroAssn. Become an AGA fan on Facebook.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/aga-arf_1051613.php
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Will Amazon raise its prices?
Razor-thin margins and several new investments led to a profit loss for Amazon in 2012. Will Amazon's shoppers pay the price?
An Amazon.com package is prepared for shipment by a United Parcel Service driver in Palo Alto, Calif. Amazon had a revenue gap in 2012, and it may well be consumers who foot the bill.
Paul Sakuma/AP/File
EnlargeIn its fourth quarter earnings report, Amazon reported a net sales increase of 27%, raising its sales revenue to $61.09 billion. The retail giant's operational costs also went down by 22% to $676 million, but Amazon ended its year in the red with a net loss of $39 million, compared to its net income of $631 million in 2011.
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The company's lack of profits in 2012 are mostly a result of Amazon's hefty investments and overall thin profit margins. And while no expert blames customers for not buying enough, it very well may be Amazon shoppers who will pay the price to make up for that revenue gap.
Consumers Could Be Paying for Amazon's Lack of Profits
These costly investments include developing 20 new fulfillment centers (making for a total of 89) and hiring 50,000 temporary workers during the holidays. Additionally, the Kindle and Amazon's video service are not very lucrative for the retail giant. According to Forbes, Amazon has been subsidizing the cost of the Kindle Fire in "order to gain a foothold in the market for tablets." Amazon also invested more in its video services last year: the company added 19 million pieces of digital media in 2011, all at no small price tag.
And while investments account for a portion of lost profits, Amazon's own price points may also be a factor. The company is famous for deep discounts on everything from socks to small kitchen appliances ? a reputation it needs in order to keep a competitive edge. But low prices also mean all-around thin profit margins.
Independent analyst Paul Santos thinks that as Amazon continues to sell more products every year, the cost of selling will increase faster than revenue will, if the retailer continues to offer those famously low prices. In other words, Amazon won't be able to make a profit by selling greater quantities of goods at rock bottom prices. Instead, to boost profits, Santos thinks Amazon will have to raise prices. And it may have already. According to Santos, a number of Subscribe & Save products have gone up in price, some of which went "above and beyond any reasonable level, to the point where customers started finding out that much of the stuff they were buying could be had cheaper in the offline world."
What's more, a recent Kantar Retail study found that Amazon might not be the cheapest place to shop for grocery and household items to begin with. Kantar Retail shopped for 36 different products at Amazon, Walmart.com, and in Walmart's brick and mortar stores. The result ? Amazon was 25% more expensive than Walmart, and 12.2% more expensive than Walmart.com.
So what does this mean for the everyday Amazon shopper? Well, if Amazon's calculated investment in the Kindle gives it the foothold it was hoping for ? and more customers start renting digital books, movies, and TV shows from Amazon's digital services ? profits should rise without us suffering sticker shock. But if Amazon's long-term plan to lower prices and "invest heavily in the future" fails and the retailer can't improve its profit margins by business development alone, the company may turn to raising its prices.
If that's the case, would you continue to buy from Amazon, readers? Or would you turn to other online retailers for potentially cheaper items?
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/haIpsKJi77Y/Will-Amazon-raise-its-prices
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Saturday, May 18, 2013
Video: Are Investors All-In on the Rally?
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Source: http://www.nbcnews.com/video/cnbc/51923101/
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Report: Michael Phelps planning comeback
Is Michael Phelps planning a comeback?
A report Friday night from WBBH, an NBC television affiliate in Fort Myers, Fla., said Phelps will return to swimming with an eye toward competing at the 2016 Rio Olympics. The three-paragraph story on the station's Web site was posted by news anchor Peter Busch, who is the son of Frank Busch, director of the U.S. national swim team.
"The greatest Olympian of all time isn't hanging up his swimsuit, after all," the report said, without citing any sources.
Phelps went on Twitter to downplay the report, but he didn't specifically deny it either.
"Why do I keep getting texts about coming back?" he wrote. "Do (people) really believe everything they hear or read? There are (too) many (people) in the world that think they have a 'story.'"
Busch followed with a tweet that said he felt "very confident with my info. Guess we'll see."
Phelps has said repeatedly his swimming career was over after winning 18 gold medals and 22 medals overall, both totals far more than any other Olympian. He retired at the age of 27 immediately after last summer's London Games.
There was no other immediate comment from the Phelps camp. A message was left with one of his longtime agents, Drew Johnson.
Officials at USA Swimming also didn't immediately respond to a request for comment.
Just last weekend, longtime rival Ryan Lochte was clearly skeptical that Phelps would stick with his decision to retire from a sport he dominated for the past decade, especially when so many swimmers are competing well into their 30s.
"I can't really talk about it," Lochte said, breaking into a sly grin during a Grand Prix meet in Charlotte, N.C. "Who knows?"
In an interview last December with The Associated Press, after beating out LeBron James for male athlete of the year, Phelps stressed repeatedly that he had no plans to return to competitive swimming.
He said London, where he captured four gold medals and two silvers, was the perfect way to close his career.
"I wanted to leave that way," he said. "I'm sure I could come back in another four years, but why? I've done everything I wanted to do. There's no point in me coming back. Everybody is like, 'You're going to come back.' And I'm like, 'No, I'm not.' I've done everything I wanted to do in this sport. I don't know a lot of people who can say that."
After the Olympics, Phelps turned his attention to golf, filming a show with famed instructor Hank Haney for the Golf Channel, signing an endorsement deal with Ping and indicating a desire to see how far he could progress with a new sport. He even joked that the only way he would compete in Rio would be if he qualified in golf, which is rejoining the Olympic program in 2016.
Last week, Phelps participated in an event prior to the Tour Championship at the TPC Sawgrass in Florida.
He also cheered his hometown Baltimore Ravens on their way to the Super Bowl, attending the title game at New Orleans with a large group of family and friends.
Phelps apparently spent Friday swimming at the Interlachen Country Club in Edina, Minn. Lifeguard Stephen Timmes posted a picture on Instagram that showed Phelps, looking extremely fit if not in top condition, smiling and posing poolside.
"Lifeguarded for and swam with Michael Phelps at work today," Timmes wrote. "I love my job."
If Phelps does come back, he would have to wait at least nine months to swim in a sanctioned event under the world anti-doping policy, meaning there's no chance of competing at this summer's world championships in Barcelona even if he could somehow get into condition.
That would peg his return to competition at sometime early next year, leaving plenty of time to get in peak shape and begin gearing up for the 2015 worlds in Russia and, of course, the next Olympics.
The timing of the report was intriguing. Phelps' coach, Bob Bowman, took a sabbatical from the deck after London but was set to work with a group including three-time Olympic gold medalist Allison Schmitt during high-altitude workouts at the national training center in Colorado Springs, leading up to the national championships in Indianapolis next month. Bowman also is coaching the U.S. men's team in Barcelona.
There was no word on whether Phelps might be among the swimmers taking part in the Colorado workouts.
___
Follow Paul Newberry on Twitter at www.twitter.com/pnewberry1963
Source: http://news.yahoo.com/report-michael-phelps-planning-comeback-024432341.html
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Nanotechnology could help fight diabetes
Friday, May 17, 2013
Injectable nanoparticles developed at MIT may someday eliminate the need for patients with Type 1 diabetes to constantly monitor their blood-sugar levels and inject themselves with insulin.
The nanoparticles were designed to sense glucose levels in the body and respond by secreting the appropriate amount of insulin, thereby replacing the function of pancreatic islet cells, which are destroyed in patients with Type 1 diabetes. Ultimately, this type of system could ensure that blood-sugar levels remain balanced and improve patients' quality of life, according to the researchers.
"Insulin really works, but the problem is people don't always get the right amount of it. With this system of extended release, the amount of drug secreted is proportional to the needs of the body," says Daniel Anderson, an associate professor of chemical engineering and member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.
Anderson is the senior author of a paper describing the new system in a recent issue of the journal ACS Nano. Lead author of the paper is Zhen Gu, a former postdoc in Anderson's lab. The research team also includes Robert Langer, the David H. Koch Institute Professor at MIT, and researchers from the Department of Anesthesiology at Boston Children's Hospital.
Mimicking the pancreas
Currently, people with Type 1 diabetes typically prick their fingers several times a day to draw blood for testing their blood-sugar levels. When levels are high, these patients inject themselves with insulin, which breaks down the excess sugar.
In recent years, many researchers have sought to develop insulin-delivery systems that could act as an "artificial pancreas," automatically detecting glucose levels and secreting insulin. One approach uses hydrogels to measure and react to glucose levels, but those gels are slow to respond or lack mechanical strength, allowing insulin to leak out.
The MIT team set out to create a sturdy, biocompatible system that would respond more quickly to changes in glucose levels and would be easy to administer.
Their system consists of an injectable gel-like structure with a texture similar to toothpaste, says Gu, who is now an assistant professor of biomedical engineering and molecular pharmaceutics at the University of North Carolina at Chapel Hill and North Carolina State University. The gel contains a mixture of oppositely charged nanoparticles that attract each other, keeping the gel intact and preventing the particles from drifting away once inside the body.
Using a modified polysaccharide known as dextran, the researchers designed the gel to be sensitive to acidity. Each nanoparticle contains spheres of dextran loaded with an enzyme that converts glucose into gluconic acid. Glucose can diffuse freely through the gel, so when sugar levels are high, the enzyme produces large quantities of gluconic acid, making the local environment slightly more acidic.
That acidic environment causes the dextran spheres to disintegrate, releasing insulin. Insulin then performs its normal function, converting the glucose in the bloodstream into glycogen, which is absorbed into the liver for storage.
Long-term control
In tests with mice that have Type 1 diabetes, the researchers found that a single injection of the gel maintained normal blood-sugar levels for an average of 10 days. Because the particles are mostly composed of polysaccharides, they are biocompatible and eventually degrade in the body.
The researchers are now trying to modify the particles so they can respond to changes in glucose levels faster, at the speed of pancreas islet cells. "Islet cells are very smart. They can release insulin very quickly once they sense high sugar levels," Gu says.
Before testing the particles in humans, the researchers plan to further develop the system's delivery properties and to work on optimizing the dosage that would be needed for use in humans.
###
Massachusetts Institute of Technology: http://web.mit.edu/newsoffice
Thanks to Massachusetts Institute of Technology for this article.
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Source: http://www.labspaces.net/128296/Nanotechnology_could_help_fight_diabetes
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Friday, May 17, 2013
Guest Bloggers - Eating Disorders Blogs
A Unique Depiction of How One Woman Exposed Distorted Ideas Around Body Image, Weight, and Health
By Lisa Kantor, Esq. & Rachel Teicher
Kantor & Kantor, LLP
I was traveling with students in Barcelona in the summer of 2011, walking through La Rambla, when I noticed two guys making fun of me. I could see them in the reflection of a mirrored building, making gestures with their hands to suggest how much bigger I was than the thin girl standing next to me, her small waist accentuated by her crop top and cut-off shorts. They painted her figure in the air like an hourglass. Then they painted my shape like the convex curves of a ball. The guys were saying something, too, but there was only one word I could make out: Gorda. Fat woman.
Haley Morris-Cafiero, a Memphis based photographer, has uncovered and displayed weight stigma with an unusual and eye-opening social experiment. Using film to capture and defy the reactions of those around her, Morris-Cafiero found a bold way to expose what seems to be a collective and steadfast weight bias.
Reflecting back internalized attitudes about weight, Marris-Cafiero reverses the gaze of those around her through photographing and recording unmistakable weight biased reactions. Her unaltered images present a dreadful truth: weight stigma is pervasive throughout the entire world.
Weight stigma is defined as shame or judgment placed upon individuals based on weight or body size. One might experience judgment of character, work ethics, and personality based on weight - communicated both directly and indirectly. This stigma can be displayed through negative attitudes, subtle and overt expressions, prejudice and discrimination, inequalities in employment, health-care, and educational settings.
?There are so many people in the world who feel they have the right ? no, the obligation ? to criticize someone for the way they look, and to be that recipient of those insults can feel so lonely,? Morris-Cafiero explains.
Morris-Cafiero?s photographic series, titled ?Wait Watchers,? is exactly as it sounds. She positions herself and the camera in a "public setting abundant with people"?and waits. Seeking out spaces that are visually interesting and geographically diverse, Morris-Cafiero performs ordinary tasks in public places - capturing not only her solitude in a busy crowd, but the appalling reactions that have contributed to her feeling ?left out and awkward.? Her honest examination of how a larger body fits into society is artistically clever, her photographs are eloquent, and the reactions to her larger body are alarming.
?I?ve been hearing comments like this for much all my life.? Morris-Cafiero said. ?Maybe someone else would have yelled at them, or shrunk inside. But I don?t get upset when this happens.? Morris-Cafiero does not waste time confronting people (who likely hold deep set ideas about weight); rather she remains calm and sets up her camera. Her photographs alone expose the gross injustices of the stigma she receives. For a full profile, click here.
Those of us familiar with the dangers of weight stigma will likely find the responses and reactions (captured so expressively by her photographs) to be outrageous, disgraceful, and intolerant. But there are many who will not see anything wrong with the captured reactions. And therein lies part of the reason for Morris-Cafiero's photographic exposition, to shine light on the fact that: weight-bias and weight stigma is a cultivated and lingering prejudice, which seems to be socially acceptable and internationally understood.
With harmful ideas about weight so entrenched and widespread, how can we begin to educate others on the damage of this stigmatizing and hostile climate?
In addition to inventive individual responses like Morris-Cafiero, you can join a larger and more collective movement to absorb the latest research and information on health, weight, and wellness. ASDAH (the Association for Size Diversity and Health), an international organization dedicated to shifting these antiquated and pervasive ideas about weight and health, was created as a peace movement: promoting education, research, and the provision of services which enhance health and well-being, and which are free from weight-based assumptions and weight discrimination. They have a strong mission which follows the Health at Every Size (HAES) principles, explaining that everyone has the right to be peaceful in their own body. HAES is a simple measure with important goals:
- Accepting and respecting the diversity of body shapes and sizes.
- Recognizing that health and well-being are multi-dimensional and that they include physical, social, spiritual, occupational, emotional, and intellectual aspects.
- Promoting all aspects of health and well-being for people of all sizes.
- Promoting eating in a manner which balances individual nutritional needs, hunger, satiety, appetite, and pleasure.
- Promoting individually appropriate, enjoyable, life-enhancing physical activity, rather than exercise that is focused on a goal of weight loss.
Much of the panic and stigma around weight has been fostered by the ?obesity epidemic,? anti-obesity campaigns, and uninformed ideas about weight and health. There is considerable scientific evidence supporting the HAES approach, establishing that ?obesity? is not the health risk it has been reported to be:
- Weight and BMI are poor predictors of disease and longevity. The bulk of epidemiological evidence suggests that five pounds ?underweight? is more dangerous than 75 pounds ?overweight.?
- Multiple studies are suggesting that a focus on weight as a health criterion is often misdirected and harmful.
- In a study comparing the HAES? model to a diet approach, though only dieters lost weight, both groups initially had similar improvements in metabolic fitness, activity levels, psychological measures, and eating behaviors. After two years, dieters had regained their weight and lost the health improvements, while the HAES? group sustained their health improvements.
See https://www.sizediversityandhealth.org/content.asp?id=161 Deb Burgard, a Psychologist and expert in HAES, illuminates the urgency of eliminating body shaming and weight discrimination. ?Having the privilege of seeing that weight and health are not inevitably linked, and seeing the terrible toll of weight preoccupation/obsession on my patients across the weight spectrum, as well as learning that people can accept and love the bodies they have, have all made me a passionate advocate for a change in our clinical interventions and public health messages.?
Although many people exhibit weight biased behaviors and do not understand the implications, weight discrimination is a human rights issue that demands attention and resolution. John F. Kennedy expressed the concept of change beautifully, ?Peace is a daily, a weekly, a monthly process, gradually changing opinions, slowly eroding old barriers, quietly building new structures.? Activists such as Haley Morris-Cafiero and Deb Burgard, and organizations like ASDAH have spoken out against the standard, demanding change, equality, and peace for any body size.
Suzanne Dooley-Hash, MD (Department of Emergency Medicine at the University of Michigan, medical director at the Center for Eating Disorders) has described weight stigma as ?The last socially-acceptable prejudice.?
The time for change is now.
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NYC's Chief Digital Officer Rachel Haot on borough hopping with Google Maps and the Macintosh II
Every week, a new and interesting human being tackles our decidedly geeky take on the Proustian Q&A. This is the Engadget Questionnaire.
This week's edition of our regular session on inquiry chats with the nation's first Chief Digital Officer, Rachel Haot. NYC's CDO discusses navigating the five boroughs with Google Maps and her filtered photo obsession. Head on past the jump for the full set of responses.
Filed under: Misc
Source: Distro Issue 91
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New Faces, New Places
Over the last several weeks, you may have noticed some changes at Gizmodo?and not just the layout. We've been sharpening our coverage of design, concepts, and the objects and ideas that are shaping our world, and growing our team to help us do it. Now it's time to meet the people who are leading that charge?starting with our new Editor in Chief, Geoff Manaugh.
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